Heart is one of the most important organ in human living. Once its work is interrupted by oxidative substance, it will create disease. Across the world, they are around 500 million people living with heart and circulatory diseases. Due to lifestyle, ageing, growing population, this number has been rising. In 2019, it’s estimated that globally there are 290 million women (53%) and 260 million men living with this heart disease. Based on British Heart Foundation, Heart and Circulatory diseases are number one the world’s biggest killer, followed by stroke was the second biggest.